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PubMed · 7605908

Acetylcholine esterase and peripherin mRNA level decrease in wobbler mouse.

R Pernas-Alonso·A E Schaffner·C T Hansen·J L Barker·U di Porzio
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Abstract

Homozygote wobbler mice develop motoneurone degeneration. Throughout development the expression of choline acetyltransferase, of trkC receptor and F3 adhesion molecule genes is similar in wobbler and wild-type spinal cord. Acetylcholinesterase mRNA level instead is decreased to about 50% with respect to wild-type values in one forth of P5 and P10 wobbler progeny, putative wr/wr individuals; at P21 its expression is equally highly reduced in known homozygotes and it is reduced to 35% of normal values in about one half of the progeny, putative heterozygotes. Thus, similarly to medium neurofilament gene over-expression, reduced acetylcholinesterase gene expression is an early molecular marker for the wobbler mutation before onset of the illness.

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AcetylcholinesteraseAnimalsBase SequenceCell Adhesion Molecules, NeuronalGene Expression Regulation, DevelopmentalIntermediate Filament ProteinsMembrane GlycoproteinsMiceMice, Neurologic MutantsMolecular Sequence DataMotor NeuronsNerve Tissue ProteinsNeuropeptidesPeripherinsPolymerase Chain ReactionRNA, MessengerReceptor Protein-Tyrosine KinasesReceptor, trkCReceptors, Nerve Growth FactorReference ValuesSpinal CordJournal ArticleResearch Support, Non-U.S. Gov't

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R Pernas-Alonso, A E Schaffner, C T Hansen, J L Barker, U di Porzio. 1995-03-07. Acetylcholine esterase and peripherin mRNA level decrease in wobbler mouse.. https://doi.org/10.1097/00001756-199503000-00003

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