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PubMed · 7573129

Interstitial duplication 19p.

R F Stratton·B R DuPont·A S Olsen·A Fertitta·M Hoyer·C M Moore
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Abstract

We report on a 9-month-old girl with an interstitial duplication of 19p, developmental delay, and multiple anomalies including bifrontal prominence, obtuse frontonasal angle, short columella, additional midline philtral pillar, midline ridge on the tongue, vertical midline ridge at the mental symphysis, and a complex congenital heart defect including severe branch pulmonary artery stenosis, secundum atrial septal defect (ASD), and several ventricular septal defects (VSDs). Use of fluorescent in situ hybridization (FISH) with chromosome 19-specific probes showed a direct duplication of bands 19p13.13 and 19p13.2.

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Abnormalities, MultipleChromosome AberrationsChromosome DisordersChromosome MappingChromosomes, Human, Pair 19Developmental DisabilitiesFaceFemaleHeart Defects, CongenitalHumansIn Situ Hybridization, FluorescenceInfantMultigene FamilyJournal Article

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R F Stratton, B R DuPont, A S Olsen, A Fertitta, M Hoyer, C M Moore. 1995-07-17. Interstitial duplication 19p.. https://doi.org/10.1002/ajmg.1320570409

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