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PubMed · 7545941

The genomic structure encoding human initiation factor eIF-5A.

K Koettnitz·B Kappel·T Baumruker·J Hauber·D Bevec
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Abstract

A genomic clone encoding the human eukaryotic initiation factor 5A (eIF-5A) was isolated and its entire nucleotide sequence was determined. The whole eIF-5A coding region is not interrupted by introns. The functional eIF-5A gene is highly homologous to the corresponding complementary DNA. One single 1.4-kb transcript thereof is expressed in human cell lines. Furthermore, we also isolated and sequenced two additional eIF-5A-related sequences which are, by expression and sequence analyses, identified as pseudogenes of the functional eIF-5A. The sequence homology between these pseudogenes and the functional eIF-5A is 71 and 87%.

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Base SequenceCosmidsDNA, ComplementaryHeLa CellsHumansIntronsMolecular Sequence DataPeptide Initiation FactorsRNA, MessengerRNA-Binding ProteinsSequence Homology, Nucleic AcidEukaryotic Translation Initiation Factor 5AJournal Article

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K Koettnitz, B Kappel, T Baumruker, J Hauber, D Bevec. 1994-07-08. The genomic structure encoding human initiation factor eIF-5A.. https://doi.org/10.1016/0378-1119(94)90385-9

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