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PubMed · 7517556

On producing more complexity than entropy in replication.

B K Davis
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Abstract

RNA replication in the bacteriophage Q beta system can, in principle, transmit sequence complexity at a higher rate than it increases entropy. Expanding the variety of nucleotides, through novel base-pair interactions, would move the threshold at which synthesis produces more complexity than entropy away from near equilibrium while accelerating the system approach to equilibrium. A decrease in sequence complexity during polymerization, leading to a many-to-one monomer correspondence with template, cannot be reversed, owing to symmetry restrictions. In terms of the kinetic mechanism, uncertainty associated with the the path of depolymerization yields a path entropy which selectively prolongs the reverse reaction. Together with an elevation in thermodynamic entropy, therefore, there are two possible sources of irreversibility in a physical process. Some implications of kinetic irreversibility are considered in relation to the second law of thermodynamics and to the processing and translation of mRNA.

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AllolevivirusBiophysicsGenome, ViralKineticsMathematicsModels, BiologicalQ beta ReplicaseRNARNA, ViralThermodynamicsTime FactorsJournal Article

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B K Davis. 1994-07-05. On producing more complexity than entropy in replication.. https://doi.org/10.1073/pnas.91.14.6639

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