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PubMed · 7476031

Acute repeated nicotine injections increase enkephalin and decrease AP-1 DNA binding activity in rat adrenal medulla.

M K McMillian·P M Hudson·K L Simmons·D A Dreyer·J S Hong·K R Pennypacker
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Abstract

Previously we reported that a single injection of nicotine decreased AP-1 DNA binding activity in adrenal medullae, although chronic bidaily nicotine (and saline) injections increased this binding activity [15]. Repeated acute nicotine injections (3 mg/kg i.p., 7 injections equi-spaced over a 3 h period) effectively increased adrenal tyrosine hydroxylase [3] and [Met5]enkephalin levels and also profoundly decreased adrenal medulla AP-1 DNA binding activity for over 8 h.

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Adrenal MedullaAnimalsBase SequenceDNA-Binding ProteinsDrug Administration ScheduleEnkephalinsFemaleMaleMolecular Sequence DataNicotineRatsRats, Inbred F344Transcription Factor AP-1Tyrosine 3-MonooxygenaseJournal Article

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M K McMillian, P M Hudson, K L Simmons, D A Dreyer, J S Hong, K R Pennypacker. 1995. Acute repeated nicotine injections increase enkephalin and decrease AP-1 DNA binding activity in rat adrenal medulla.. https://doi.org/10.1016/0169-328x(95)00053-u

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