[Ulcero-multilating acropathy].

N Accornero; C Argentino; A Bondoli

PubMed · 7466201

[Ulcero-multilating acropathy].

Abstract

A case of a 46 years old male suffering from chronic sensory neuropathy is reported. The symptoms consisted of superficial and deep sensory disturbances, and bilateral trophic plantar ulcerations with osteolysis, resulting in a deformity of the feet. There was an increased sweating of the distal portions of the four limbs, and a delayed adaptation of blood pressure and heart frequency to postural changes. CSF aminoacids were all increased except taurine, which was markedly descreased. An increased blood flow in lower extremities was demonstrated angiographically. The possibilities of pharmacological and surgical treatment raised by the hemodynamic hypothesis of BUREAU and BARRIERE (1957) are discussed.

Explore related subjects

Bone Resorption Diabetes Mellitus Diagnosis, Differential Foot Diseases Humans Male Middle Aged Osteolysis Syndrome Ulcer Case Reports English Abstract Journal Article

Keep this discovery

Explore connections, maps & timelines

BibTeX RIS

N Accornero, C Argentino, A Bondoli. [Ulcero-multilating acropathy].. https://pubmed.ncbi.nlm.nih.gov/7466201/

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed2007

A new reconstructive technique for intercalary defects of long bones: the association of massive allograft with vascularized fibular autograft. Long-term results and comparison with alternative techniques.

In 1988, the excellent results obtained with the use of vascularized fibular autograft as a salvage procedure in massive allograft failures caused by non-union or massive resorption prompted a trial of an original reconstructive technique for intercalary defects based on the primary combination of the two types of graft. The authors believe the excellent final results and the ability to avoid further salvage surgical procedures justify the primary application of this more complicated technique despite longer surgical times.

Bone Resorption↗

PubMed2006

FSH and bone--important physiology or not?

For many years, osteoporosis in women was equated with estrogen deficiency. The recent articles by Zaidi and colleagues offer a new challenge to the estrogen-deficiency-osteoporosis hypothesis by showing that follicle-stimulating hormone (FSH) stimulates osteoclastic bone resorption perhaps through tumor necrosis factor-alpha (TNF-alpha). These authors, however, neglected to mention bone abnormalities and high testosterone levels that were previously shown in FSH-receptor knockout and other modified mice. It is also possible that they have overemphasized potential relationships of these new data with human bone loss. Despite these fascinating data, the paradigm of FSH causing hypogonadal bone loss is not yet ready to displace the estrogen-deficiency-osteoporosis paradigm, although that model already faces considerable challenge.

Bone Resorption↗

PubMed2006

Natural inhibitors targeting osteoclast-mediated bone resorption.

Human cathepsin K, matrix metalloproteinase 9, and alpha(V)beta(3) integrin are the key regulators in osteoclast-mediated bone resorption. In this paper, we found natural inhibitors 1-10 for them by enzyme inhibition assays. Inhibitors 1-7, 8-9, and 10 are novel inhibitors of human cathepsin K, matrix metalloproteinase 9, and alpha(V)beta(3), respectively.

Bone Resorption↗