PubMed · 7353112
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P Vestergaard. 1980-01-12. Sustained-release lithium tablets and renal function.. https://doi.org/10.1136/bmj.280.6207.113-c
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Controlled release drug delivery systems offer great advantages over the conventional dosage forms. However, there are great challenges to efficiently develop controlled release drug delivery systems due to the complexity of these delivery systems. Traditional statistic response surface methodology (RSM) is one of the techniques that has been employed to develop and formulate controlled release dosage forms. However, there are some limitations to the RSM technique. Hence, another technique called artificial neural networks (ANN) has recently gained wide popularity in the development of controlled release dosage forms. In this review, the basic ANN structure, the development of the ANN model and an explanation of how to use ANN to design and develop controlled release drug delivery systems are discussed. In addition, the applications of ANN in the design and development of controlled release dosage forms are also summarized in this review.
The disassembly of dendritic structures was realized by a cascade cleavage reaction triggered by an initially stimulated group in the dendrimer periphery. A depolymerizable backbone was engineered into prototypical dendritic structures. Evidence for the completion of the disassembly process is provided by the absorbance peak of the p-nitrophenoxide ion that was intentionally installed at the focal point of the dendrons. Observation of the UV spectra during the disassembly process supports a stepwise cascade cleavage proceeding from the periphery into the core.
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