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PubMed · 7263964

Dilantin digital defects.

R B Johnson·L A Goldsmith
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Abstract

Diphenylhydantoin (phenytoin) is a widely used drug with multiple adverse effects, several of them cutaneous. Prenatal exposure to hydantoins may result in a spectrum of structural, developmental, and behavioral changes known as the fetal hydantoin syndrome (FHS). A patient with the dysmorphic characteristics of FHS had unusual hyperpigmentation of several fingernails, a finding which has not been described in other patients with FHS. We propose a mechanism for the dysmorphic action of phenytoin on the developing fetus, consonant with the known effects of hydantoins on collagen metabolism.

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Abnormalities, Drug-InducedChildFemaleFingersHumansNail DiseasesPhenytoinPigmentation DisordersCase ReportsJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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BibTeXRIS

R B Johnson, L A Goldsmith. 1981. Dilantin digital defects.. https://doi.org/10.1016/s0190-9622(81)70087-2

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