PubMed · 7257908
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M M Verea Hernando, A García Esperón, M J Cruces Prado, A Robledo Aguilar. [Multiple hyperkeratotic angiomas].. https://pubmed.ncbi.nlm.nih.gov/7257908/
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A pictorial review of the many clinical manifestations of lymphatic malformations is presented, changes to the terminology of lymphatic malformations are reviewed and the 'pros and cons' of relevant investigative techniques are discussed.
We report a plasma cell granuloma arising in the movable mucosa of the oral cavity of a 50-year-old man. Histologically, the lesion was characterized by a dense nodular infiltrate of mature plasma cells. Immunostaining for kappa and lambda light chains confirmed a polyclonal plasma cell population. Elongated rete ridges of the overlying epithelium formed collarettes around dilated blood and lymph vessels in focal areas. Based on the overall histologic architecture, we hypothesize that these peculiar changes are secondary to local blood flow alteration with congestive vasodilation caused by a dense plasma cell infiltrate. We believe that the plasma cell population may represent the oral counterpart of the cutaneous angioplasmocellular hyperplasia.
We report a case of angiokeratoma circumscriptum which we have followed for one year. The skin lesion initially showed erythema and then changed to a dark reddish, raised, keratotic nodule. The lesion histologically showed dilated capillaries and hyperkeratosis. Using immunohistochemistry, matrix metalloproteinase (MMP)-9 was localized in the epidermis just under the horny layer, particularly in the hyperkeratotic lesion. The expression of MMP-9 might be related to the hyperkeratotic changes in this lesion.