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PubMed · 715443

Decrease in adrenergic axon sprouting in the senescent rat.

S W Scheff·L S Bernardo·C W Cotman
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Abstract

When the septal area in young adult rats is denervated by a lesion of the fimbria-fornix, adrenergic fibers proliferate within the denervated area. The same operation performed on aged animals gives rise to a qualitatively similar but quantitatively less pronounced response. This reduction in reactive growth may reflect a decreased capacity of the aged brain to remodel its circuitry and restore lost function.

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Adrenergic FibersAgingAnimalsCell DifferentiationHippocampusMaleRatsSeptal NucleiJournal Article

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S W Scheff, L S Bernardo, C W Cotman. 1978-11-17. Decrease in adrenergic axon sprouting in the senescent rat.. https://doi.org/10.1126/science.715443

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