PubMed · 7151989
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M Klitsch. Sterilization without surgery.. https://pubmed.ncbi.nlm.nih.gov/7151989/
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The pi-A isotherms of mixed monolayers of cyclosporin and poly(isobutylcyanoacrylate) (PIBCA) show that the molecular areas of cyclosporin and PIBCA are additive regardless of the pH of the substrate or the physical state of the monolayers. All these mixed films collapse at the same surface pressure; therefore, application of the two-dimensional phase rule implies that cyclosporin and PIBCA are immiscible at the interface. This conclusion may have important implications with regard to the formulation of PIBCA-cyclosporin nanoparticles for cyclosporin administration, though further research in this direction will require consideration of the role played by the coadjuvants used for PIBCA polymerization during nanoparticle formation.
The primary surgical tissue adhesives used in otolaryngology-head and neck surgery include the cyanoacrylate derivatives and the fibrin tissue adhesives. The cyanoacrylate derivatives are effective for superficial skin closure. Use of this material below the level of the skin can result in acute and chronic inflammation and tissue necrosis. Fibrin tissue adhesives can be used for wound closure, tissue sealing, and hemostasis. Drawbacks noted with the fibrin tissue adhesives include method of preparation, relatively low binding strength, and variable resorption time. This article discusses the properties, methods of preparation, and clinical indications of the cyanoacrylate derivatives and fibrin tissue adhesives.
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