Search PubMed⌕ Search
Home/Archive/PubMed

PubMed · 7109618

Washington report.

J Lewis
View original source ↗Export metadata ↓

Abstract

The source did not provide an abstract. Follow the original record for more information.

Explore related subjects

AlcoholismFinancing, GovernmentHumansNational Institutes of Health (U.S.)Research Support as TopicUnited StatesJournal Article

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

J Lewis. 1982. Washington report.. https://doi.org/10.15288/jsa.1982.43.183

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed1998

Serotonin function and risk for alcoholism in boys with attention-deficit hyperactivity disorder.

Data in animals and adults indicate that central serotonergic (5-HT) function may be involved in the development of alcohol abuse. Despite this, studies exploring this mechanism in individuals at risk for alcoholism are scant. This study used a fenfluramine (FEN) challenge procedure to investigate the relationship between risk for alcoholism and 5-HT function in 7- to 11-year-old boys with attention-deficit hyperactivity disorder (ADHD). The prolactin (PRL) and cortisol (CORT) responses to FEN were examined in 10 sons of alcoholic fathers (FA+) and 30 sons of nonalcoholic fathers (FA-). The FA+ group had a significantly greater CORT, but not PRL, response to FEN relative to the FA- group. The discrepancy between the CORT and PRL responses may be due to the different mechanisms that underlie their 5-HT stimulated release. This suggests that, among ADHD boys, those at familial risk for alcohol abuse may differ from those who are not at risk in 5-HT function.

Alcoholism↗