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PubMed · 7095079

Decrease of carbon tetrachloride liver toxicity in rats given dipyridamole.

A Kast·J Nishikawa·T Yabe
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Abstract

The influence of Dipyridamole on acute hepatotoxicity has been studied in male SD-JCL rats doses with carbon tetrachloride. High single oral doses of Dipyridamole lowered the serum enzyme activity and reduced significantly the area % of hepatic necrosis and hydropic degeneration, but not of steatosis. Dipyridamole was effective from 1 hr before through 6 hrs after the oral administration of CCl4. Doses below 1,000 mg/kg Dipyridamole were less effective. No delay in the onset of CCl4-induced liver damages was observed. Dipyridamole was also effective when CCl4 toxicity was enhanced by isopropanol.

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1-PropanolAnimalsBody TemperatureCarbon TetrachlorideDipyridamoleDose-Response Relationship, DrugLiverMaleNecrosisRatsJournal Article

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A Kast, J Nishikawa, T Yabe. 1982. Decrease of carbon tetrachloride liver toxicity in rats given dipyridamole.. https://doi.org/10.1016/s0232-1513(82)80061-3

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