Chronic phencyclidine, like amphetamine, produces a decrease in [3H]spiroperidol binding in rat striatum.

H A Robertson

doi:10.1016/0014-2999(82)90039-5

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Chronic phencyclidine, like amphetamine, produces a decrease in [3H]spiroperidol binding in rat striatum.

H A Robertson

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Abstract

Rats were treated with d-amphetamine sulfate (5 and 10 mg/kg i.p.) and phencyclidine (PCP) (5 mg/kg i.p.) twice per day. After 21 days, [3H]spiroperidol binding in striatum was reduced by all treatments; receptor number (Bmax) and not affinity (KD) was affected. These results suggest that the psychotic effect of PCP may, like those of amphetamine, involve changes in dopamine receptors.

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Amphetamine Animals Butyrophenones Corpus Striatum Depression, Chemical In Vitro Techniques Kinetics Male Phencyclidine Rats Rats, Inbred Strains Spiperone Journal Article Research Support, Non-U.S. Gov't

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H A Robertson. 1982-03-12. Chronic phencyclidine, like amphetamine, produces a decrease in [3H]spiroperidol binding in rat striatum.. https://doi.org/10.1016/0014-2999(82)90039-5

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