PubMed · 7013571
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1980. Restorative materials.. https://pubmed.ncbi.nlm.nih.gov/7013571/
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The aim of this 2-year prospective randomized clinical study was to evaluate the efficacy of a prevention program for schoolchildren with high caries risk. A sample of 419 subjects was divided into a test (T, n = 259) and control group (C, n = 160). Four times a year, the test group received professional tooth-cleaning and application of a 0.1% fluoride varnish as well as motivation and instruction in oral hygiene. The control group received only oral hygiene instruction and took part in supervised toothbrushing once a year. At baseline and after 2 years, the D3,4MFS and the incipient lesions (D1,2) were recorded. After 2 years, 318 subjects (T = 187, C = 131) were included in the data analysis. The baseline D1,2 was 6.18 (T) and 5.50 (C), the D3,4MFS 2.13 (T) and 2.08 (C), respectively. No statistically significant difference was found for the baseline values. At the final examination, the D1,2 increment was 3.96 in the test and 6.53 in the control group, showing a statistically significant difference (P < 0.001). No such difference was found for the D3,4MFS increment (T: 2.22; C: 2.61). The results indicate that it might not be possible to prevent cavities in high caries risk children by means of the described program.
This paper reviews current ideas relating to oral fluoride retention after topical applications of various fluoride preparations. The oral fluoride reservoirs, which serve as a store for fluoride, gradually releasing its content into saliva, will be discussed. The present paper also deals with fluoride kinetics in the oral cavity. The answer to the title of the paper has, however, not yet been found but remains a goal for researchers studying caries prophylaxis worldwide in the search for possible ways of increasing and improving oral fluoride retention.
The 1,500 ppm fluoride (F(-)) concentration limit set up for European cosmetic toothpaste needs to be considered in terms of effectiveness and toxicity. There is clear evidence for a dose-response relationship between F(-) concentration and caries-preventive effect (25-30% caries reduction achieved with a 1,000 ppm F(-) dentifrice). Clinical significance of higher F(-) concentration has not been totally proven. Low F(-) toothpastes (<500 ppm F(-)) have been marketed to reduce F(-) ingestion by young children in order to minimize the risk of dental fluorosis. Their effectiveness is, however, unclear. Fluoride intake and caries risk assessment should be performed by dental professionals and prescription of topical fluoride should be adjusted individually.