PubMed · 6925264
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W Hamerski. 1982. [Alcoholic intoxication].. https://pubmed.ncbi.nlm.nih.gov/6925264/
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This chapter reviews data on estimated blood alcohol concentration (BAC), self-reported consumption, and drinking patterns and problems from emergency room (ER) studies of alcohol and violence-related injury. These studies used probability samples of all injured patients that were representative of the population served by the ER where the data were collected. Those with violence-related injuries were more likely to be admitted to the ER with a positive BAC, to report drinking prior to the event, and to report more frequent heavy drinking and alcohol-related problems than those admitted to the same ER during the same time period with injuries from other causes. Limitations to these ER studies, including representativeness of samples, alcohol's presence and role in violence perpetration compared to violence victimization, the presence of other psychoactive substances, and the actual risk at which alcohol places the individual for injuries resulting from violence are discussed.
Initial insensitivity to alcohol is a strong predictor of human alcoholism, a widespread and heritable health problem. The Long Sleep and Short Sleep lines of mice were developed by genetic selection for high or low alcohol sensitivity. We have identified seven quantitative trait loci (QTLs) specifying differences in alcohol sensitivity using intercross progeny from these selected strains. These QTLs (Lorel-Lore7) together account for approximately 60% of the total genetic variance for this trait. This represents the first report of linkages for genes influencing alcohol action in any mammalian system using stringent, genome-wide mapping criteria.