PubMed · 6835748
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B Forsyta. 1983. A partially blind study.. https://pubmed.ncbi.nlm.nih.gov/6835748/
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Infantile colic occurs in 1/3 of all infants and is still a medical mystery. This paper reviews the etiology and the documented therapies. The overall aim is to avoid that inefficient forms of medication are used for this indication. It is not yet known whether colic is a dysfunction related to physical pain or behaviour. The results from 885 infants born in Oslo suggested that colic was frequent among those whose mothers both breastfed them and smoked more than five cigarettes daily. No increase in relative risk was found for other maternal or demographic factors. Since it is impossible to treat the causes parents should be advised to try general and specific strategies. General advice includes support, interest and care from health personnel and assistance from relatives. Specifically, some infants respond to either dietary changes (no cow's milk), oral sucrose infusion, vibro-accustic treatment, behavioural therapy or carrying, but avoiding hyperstimulation. Nicotine-free breast milk has not been evaluated. The available pharmacotherapy is not efficacious. Alternative medicine (herbal teas, chiropractic, acupuncture), has not yet been proven to be efficacious.
Oligohydramnios induced by indomethacin has been documented both clinically and experimentally. The same is not true for all the drugs inhibiting the synthesis of prostaglandins. The case of a full term pregnant woman diagnosed with renal cholic and treated with high doses of magnesium dipyrone who developed echographically diagnosed oligohydramnios at 60 h of initiation of the treatment is presented. Delivery was induced by the double intracervical application of 0.5 mg of prostaglandin E2 over an interval of 24 h. At 35 h of the discontinuation of magnesium dipyrone the patient was echographically reevaluated with the volume of the amniotic fluid being found to be normal. Although no reports have been found concerning oligohydramnios by magnesium dipyrone, the negative effect of this drug on urine flow in healthy individuals is known. In the absence of other hypotheses, the authors suggest that the use of high doses of this drug may significantly reduce fetal urine flow and be responsible for a drastic reduction in amniotic fluid. The adverse effect was determined as possible by evaluation of secondary effects by Naranjo's algorithm.
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