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PubMed · 6763892

An association of carcinogenesis and decrease of cellular NAD concentration.

K T Chung
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Abstract

It is postulated that a decrease in nicotinamide adenine dinucleotide (NAD) concentration has a primary association with carcinogenesis. The following observations are presented as evidence: (1) NAD and adenosine triphosphate (ATP) concentrations are lower in cancer cells; (2) chemical carcinogens and radiation can cause a lowering of NAD concentration in precancerous cells: (3) biosynthesis of NAD in Ehrlich ascites tumor cells is altered; and (4) NAD is involved in regulating deoxyribonucleic acid (DNA) synthesis. The lowering of NAD concentration would lead to the expression of oncogene and/or virogene according to the protovirus hypothesis, and the cellular characteristics of cancer cells can also be explained through the lowering of cellular NAD concentration. Experimental approaches are also proposed.

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Adenosine TriphosphateAnimalsCell Transformation, ViralDNAHumansNADNeoplasmsRatsRetroviridaeJournal ArticleReview

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K T Chung. 1982. An association of carcinogenesis and decrease of cellular NAD concentration.. https://pubmed.ncbi.nlm.nih.gov/6763892/

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