PubMed · 6747801
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A Dickson. 1984. Pancreatitis.. https://pubmed.ncbi.nlm.nih.gov/6747801/
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A rapid supply of n-3 polyunsaturated fatty acids (PUFA) may be indicated in some acute conditions because of the ability of n-3 PUFA to decrease inflammatory responses and cell sensitivity to various stimuli, and to improve endothelial dysfunction. To achieve these objectives, n-3 PUFA content needs to be quickly raised in cell membranes of key organs. Intravenous fish oil (FO) emulsions are available but their slow hydrolysis limits their infusion rate. Mixtures containing both FO triglycerides and medium chain triglycerides may overcome this problem. These new preparations are rapidly cleared from plasma and efficiently deliver n-3 PUFA to several tissues, largely via direct particle uptake. Recent data suggest that n-3 PUFA incorporation in phospholipids promptly modulates important cell functions. This review also focuses on a novel approach to rapidly supply n-3 PUFA to targeted organs which may offer interesting perspectives in the management of acute illnesses.
OBJECTIVE: To understand the status of total parenteral nutritional (TPN) composition and the TPN line used for home parenteral nutrition (HPN) in Japan and to investigate how adequate nutritional support should be in HPN, we conducted a questionnaire survey. METHODS: From February to March 2004, questionnaires were sent by mail to the members of the Japan Society for Home Therapy Research. With the content of the questionnaire, we surveyed 1) the types of medical staff who are involved in HPN, 2) the status of the preparation of TPN fluid and its place of preparation, 3) use of the TPN line and final filter, and 4) administration of lipid emulsion and All-in-One. RESULTS: The major survey results from 66 respondents were that the 50% of the medical staff who are involved in HPN have more than 10 y of experience; however, the number of patients who used HPN and were treated by 78% of the medical staff was fewer than 50. With regard to TPN fluid, 50% was prepared in-house and 12% was prepared by home care service providers. In addition, 58% of institutions were infusing lipid emulsion from the side port of the TPN line or through a peripheral route because they used a final filter and closed system infusion line. CONCLUSIONS: Because the final filter and closed system infusion line for HPN management is standard practice, lipid emulsion is not adequately used in Japan. Therefore, the All-in-One system including lipid emulsion is not used.
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