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PubMed · 6722565

Age-related decrease in apomorphine modulation of acetylcholine release from rat striatal slices.

J M Thompson·C L Makino·J R Whitaker·J A Joseph
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Abstract

Release of [3H]acetylcholine ( [3H]ACh) was assessed in striatal slices from mature, middle-aged and senescent Wistar rats 8, 12 and 24 months of age, respectively. There was an age-related decline in basal release of [3H]ACh as a function of age which was correlated with a decline in accumulation of [3H]ACh. However, the most striking finding was the failure of apomorphine to inhibit KCl-induced [3H]ACh release in the senescent (24 months) animals. Striatal dopaminergic receptor losses in senescence apparently produce several subsequent changes in striatal function which ultimately result in the decline of motor-behavioral function.

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AcetylcholineAgingAnimalsApomorphineCorpus StriatumDopamineMaleNeuronsRatsRats, Inbred StrainsJournal Article

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J M Thompson, C L Makino, J R Whitaker, J A Joseph. 1984-05-07. Age-related decrease in apomorphine modulation of acetylcholine release from rat striatal slices.. https://doi.org/10.1016/0006-8993(84)90802-3

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