Abnormalities in glomerular function in rats developing spontaneous hypertension.

J R Dilley; C T Stier; W J Arendshorst

doi:10.1152/ajprenal.1984.246.1.f12

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PubMed · 6696074

Abnormalities in glomerular function in rats developing spontaneous hypertension.

J R Dilley·C T Stier·W J Arendshorst

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Abstract

Clearance and micropuncture studies were conducted on 6-wk-old spontaneously hypertensive rats (SHR) of the Okamoto-Aoki strain and normotensive Wistar-Kyoto rats (WKY) under euvolemic conditions. Mean arterial pressure in SHR was elevated by 18 mmHg and their kidneys were vasoconstricted with reduced blood flow; resistances in preglomerular vessels and efferent arterioles were elevated 2.8 and 2 times, respectively, above WKY values. Whole kidney glomerular filtration rate (GFR) and single nephron glomerular filtration rate (SNGFR), based on fluid collection from either proximal or distal convolutions, were 25-30% lower in SHR. Fractional reabsorptions of fluid load by the proximal convoluted tubule (43%) and by the loop of Henle (52-55%) were similar in both groups. Accordingly, SHR exhibited less fluid delivery from the proximal convolution (8 vs. 12 nl/min) and to the distal convolution (3 vs. 5 nl/min). Glomerular dynamics in hypertensive and normotensive strains were characterized by filtration pressure disequilibrium. Estimated glomerular capillary pressure and mean effective ultrafiltration pressure were similar in SHR and WKY. SHR had a lower glomerular ultrafiltration coefficient than WKY (0.011 vs. 0.016 nl X s-1 X mmHg-1), which, combined with a lower glomerular plasma flow (41 vs. 73 nl/min), quantitatively accounted for the lower SNGFR in 6-wk-old SHR. These findings document important differences in renal function in young SHR compared with WKY that may participate in the development of hypertension.

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Absorption Animals Glomerular Filtration Rate Hypertension Kidney Kidney Glomerulus Male Rats Rats, Inbred Strains Regional Blood Flow Vascular Resistance Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

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J R Dilley, C T Stier, W J Arendshorst. 1984. Abnormalities in glomerular function in rats developing spontaneous hypertension.. https://doi.org/10.1152/ajprenal.1984.246.1.f12

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