Search PubMed⌕ Search

PubMed · 6602243

[Cornea pseudoguttata].

Abstract

Cornea pseudoguttata is the term applied to a temporary, completely reversible lesion of the corneal endothelium during inflammations of the anterior segment of the eye. The posterior specular area of the cornea reveals numerous, partially confluent, dark holes of different sizes. At examination with the specular microscope these holes correspond to intra- and intercellular changes in the endothelial mosaic. It appears that the clinical picture of cornea pseudoguttata is caused by both the edema of the endothelial cells and the looseness of the structure of the endothelial layer due to inter- and subcellular accumulations of fluid.

Explore related subjects

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

H Slezak, G Grabner, M Stur. 1983. [Cornea pseudoguttata].. https://doi.org/10.1055/s-2008-1054697

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

TGFBI gene mutations in corneal dystrophies.

The lattice corneal dystrophies (LCD) and granular corneal dystrophies (GCD) are autosomal dominant disorders of the corneal stroma. They are bilateral, progressive conditions characterized by the formation of opacities arising due to the deposition of insoluble material in the corneal stroma leading to visual impairment. The LCDs and GCDs are distinguished from each other and are divided into subtypes on the basis of the clinical appearance of the opacities, clinical features of the disease, and on histopathological staining properties of the deposits. The GCDs and most types of LCD arise from mutations in the transforming growth factor beta-induced (TGFBI) gene on chromosome 5q31. Over 30 mutations causing LCD and GCD have been identified so far in the TGFBI. There are two mutation hotspots corresponding to arginine residues at positions 124 and 555 of the transforming growth factor beta induced protein (TGFBIp) and they are the most frequent sites of mutation in various populations. Mutations at either of these two hotspots result in specific types of LCD or GCD. The majority of identified mutations involve residues in the fourth fasciclin-like domain of TGFBIp.

Corneal Dystrophies, Hereditary↗