Search PubMed⌕ Search
Home/Archive/PubMed

PubMed · 6541761

Tolerance for the decrease in nerve conduction velocity and for the motor impairment produced by ethanol in mice: differential development during chronic ethanol consumption.

J Juntunen·T Widenius·T E Reed·R Ylikahri·E Matikainen·M Sarviharju·H Teräväinen
View original source ↗Export metadata ↓

Abstract

C57BL/6J/BOM mice were given 15% (w/v) ethanol solution as their sole drinking fluid. Nerve conduction velocities (NCV) and motor coordination (ataxia) of the unanesthetized animals were examined after a single IP injection of 3.0 g ethanol/kg body weight at 6, and 9 months after the start of drinking and after 3 months of abstinence. During chronic consumption of ethanol, tolerance for relative conduction time (RCT) change developed in six months. This tolerance was not observed after 9 months of ethanol treatment. The tolerance for ataxia persisted throughout the period of ethanol treatment. After a three month's abstinence, no differences between the controls and the animals previously on ethanol were observed regarding responses to acute ethanol administration. These observations suggest that different mechanisms underlie the development of tolerance for the effect of ethanol on peripheral nerve conductance and for the ataxia from ethanol in the central nervous system.

Explore related subjects

AlcoholismAnimalsAtaxiaDrug ToleranceEthanolHumansMaleMiceMice, Inbred C57BLNeural ConductionPsychomotor PerformanceTime FactorsJournal ArticleResearch Support, Non-U.S. Gov't

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

J Juntunen, T Widenius, T E Reed, R Ylikahri, E Matikainen, M Sarviharju, H Teräväinen. Tolerance for the decrease in nerve conduction velocity and for the motor impairment produced by ethanol in mice: differential development during chronic ethanol consumption.. https://pubmed.ncbi.nlm.nih.gov/6541761/

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed1992

Long-term mortality after transfusion-associated non-A, non-B hepatitis. The National Heart, Lung, and Blood Institute Study Group.

BACKGROUND: Acute non-A, non-B hepatitis after blood transfusion often progresses to chronic hepatitis and sometimes culminates in cirrhosis or even hepatocellular carcinoma. However, the frequency of these sequelae and their effects on mortality are not known. METHODS: We traced patients with transfusion-related non-A, non-B hepatitis who had been identified in five major prospective studies conducted in the United States between 1967 and 1980. We matched each patient with two control subjects (identified as the first and second controls) who received transfusions but who did not have hepatitis. The mortality rates in the three groups were determined with use of data from the National Death Index and Social Security Death Tapes. Cause-specific mortality was determined by reviewing death certificates. RESULTS: Vital status was established for over 94 percent of the 568 patients who had had non-A, non-B hepatitis and the two control groups (526 first controls and 458 second controls). After an average follow-up of 18 years, the estimate by life-table analysis of mortality from all causes was 51 percent for those with transfusion-associated non-A, non-B hepatitis, as compared with 52 percent for the first controls and 50 percent for the second controls. The survival curves for the three groups were virtually the same. Mortality related to liver disease was 3.3, 1.1, and 2.0 percent, respectively, among the three groups (P = 0.033 for the comparison of the group with non-A, non-B hepatitis with the combined control group). Seventy-one percent of the deaths related to liver disease occurred among patients with chronic alcoholism. CONCLUSIONS: In this long-term follow-up study, there was no increase in mortality from all causes after transfusion-associated non-A, non-B hepatitis, although there was a small but statistically significant increase in the number of deaths related to liver disease.

Alcoholism↗