Suppressor cell function in psoriasis.

D N Suader; P L Bailin; J Sundeen; R S Krakauer

doi:10.1001/archderm.116.1.51

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Suppressor cell function in psoriasis.

D N Suader·P L Bailin·J Sundeen·R S Krakauer

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Abstract

Recent studies suggest that autoimmunity may play a role in the pathogenesis of psoriasis. In view of these findings, it is postulated that the immunologic defect may be associated with regulation of the immune system. A study was undertaken to determine whether a suppressor cell defect was present. Two groups of patients with active psoriasis who were receiving no therapy were selected. Peripheral blood lymphocytes were pulsed with concanavalin A, 40 microgram/cc, for 48 hours. Their ability to suppress a mixed lymphocyte reaction with both autologous and allogeneic responding cells was assessed. There was a significant decrease in suppressor activity in psoriasis patients compared with normal individuals. Although we have not demonstrated that this mechanism is implicated directly in a causal relationship to psoriasis, it nevertheless gives further support to the possible role of the immune system in the pathogenesis of psoriasis.

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Concanavalin A Humans Immunity, Cellular Lymphocyte Activation Lymphocyte Culture Test, Mixed Psoriasis T-Lymphocytes, Regulatory Journal Article

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D N Suader, P L Bailin, J Sundeen, R S Krakauer. 1980. Suppressor cell function in psoriasis.. https://doi.org/10.1001/archderm.116.1.51

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