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PubMed · 622906

Basic concepts in immunology.

J Plum
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Abstract

The immune system exhibits the capacity to react specifically towards antigens. This capacity depends on the activation of T and B cells. The cooperation between B and T cells is necessary for the production of IgG, IgA and IgE. The productions of these antibodies together with the formation of the other immune products (IgM and sensitized T cells) result in an altered state of reactivity towards the antigen. This becomes manifest in variety of ways: from protection to destruction. In the case of allergic rhinitis the tissue damage is caused by the presence of IgE and the subsequent release of vaso active amines by the mastcell after contact with the antigen.

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AllergensAllergy and ImmunologyAntigen-Antibody ReactionsAntigensComplement System ProteinsHaptensHumansImmunoglobulinsLymphocytesJournal Article

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J Plum. 1978. Basic concepts in immunology.. https://pubmed.ncbi.nlm.nih.gov/622906/

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PubMed1979

[The atopy syndrome].

Atopy is defined as that familial form of increased reactivity which is characterized by a probably genetically determined, spontaneously occurring preferential production of IgE as a response to the natural exposure to allergens normally present in the environment, and whose clinical manifestation as a disease is additionally dependent on a non-immunologically conditioned increase in reagibility of the tissues. An attempt is made to show how many different factors must cooperate to produce atopic disease, and how these factors are mutually influenced by their actions. The implications of this definition of atopy are discussed with reference to prophylaxis and treatment in clinical practice.

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