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PubMed · 6223586

[Experimental study on immunochemotherapy using schizophyllan].

M Mitani·K Iwano·T Arika·M Kikuchi
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Abstract

Immunochemotherapy with schizophyllan (SPG) combined with chemotherapeutic agents was evaluated in two syngeneic tumor-C3H/He mouse systems. The administration of SPG alone caused a significant growth inhibition of MM 46 mammary carcinoma, the highest therapeutic effect being obtained by SPG given at the advanced stage of tumors. When combined with neocarzinostatin given 7-times every other day the simultaneous administration of SPG produced an optimal response to that therapy. In X-5563 plasmacytoma, SPG alone was ineffective. However, when combined with mitomycin C given with 1 to 5-days interval, the concurrent administration of SPG prolonged significantly the life-span of the tumor-bearing mice. These results indicated that the simultaneous administration of SPG and antitumor drugs may be a useful application method for immunochemotherapy of experimental tumors.

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Adjuvants, ImmunologicAnimalsGlycosaminoglycansMacrophage ActivationMaleMammary Neoplasms, ExperimentalMiceMice, Inbred C3HMitomycinMitomycinsNeoplasms, ExperimentalPlasmacytomaSizofiranT-LymphocytesZinostatinJournal Article

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M Mitani, K Iwano, T Arika, M Kikuchi. 1982. [Experimental study on immunochemotherapy using schizophyllan].. https://pubmed.ncbi.nlm.nih.gov/6223586/

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