Search PubMed⌕ Search

PubMed · 6202811

Do children with constitutional delay really have more learning problems?

Abstract

The source did not provide an abstract. Follow the original record for more information.

Explore related subjects

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

M Gordon, E M Post, C Crouthamel, R A Richman. 1984. Do children with constitutional delay really have more learning problems?. https://doi.org/10.1177/002221948401700509

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

Secular trend and regional differences in the stature of Italians, 1854-1980.

We present 127 years of data on the physical stature of military conscripts born in Italy during 1854-1980, as well as an analysis of regional variations in height (for birth cohorts born during 1927-1980). The height of young men has increased in all regions of Italy. The secular trend and the regional changes in stature are correlated with economic growth and a general improvement of living conditions. This is suggested by the relationship between height and various socio-economic indicators. A comparison of the 1927 birth cohort with the 1980 birth cohort shows that the mean heights for populations in Italy's southern areas, which were shorter than the national average in 1927, underwent the largest increases. In recent years, mean height has been gradually approaching an upper bound for all regions in Italy, with the exception of some central and southern regions. A multiple regression analysis evaluates the impact of living conditions on the convergence of regional heights.

Body Height↗

Catch-up growth up to ten years of age in children born very preterm or with very low birth weight.

BACKGROUND: Improved survival due to advances in neonatal care has brought issues such as postnatal growth and development more to the focus of our attention. Most studies report stunting in children born very preterm and/or small for gestational age. In this article we study the growth pattern of these children and aim to identify factors associated with postnatal catch-up growth. METHODS: 1338 children born with a gestational age <32 weeks and/or a birth weight of <1500 grams were followed during a Dutch nationwide prospective study (POPS). Subgroups were classified as appropriate for gestational age and <32 weeks (AGA) or small for gestational age (<32 wks SGA and > or =32 wks SGA). Data were collected at different intervals from birth until 10 years for the 962 survivors and compared to reference values. The correlation between several factors and growth was analysed. RESULTS: At 10 years the AGA children had attained normal height, whereas the SGA group demonstrated stunting, even after correction for target height (AGA: 0.0 SDS; SGA <32 wks: -0.29SDS and > or =32 wks: -0.13SDS). Catch-up growth was especially seen in the SGA children with a fast initial weight gain. BMI was approximately 1 SD below the population reference mean. CONCLUSION: At 10 years of age, children born very preterm AGA show no stunting. However, many children born SGA, especially the very preterm, show persistent stunting. Early weight gain seems an important prognostic factor in predicting childhood growth.

Body Height↗

Endocrine manifestations of chromosome 22q11.2 microdeletion syndrome.

BACKGROUND: Endocrine abnormalities, including hypocalcemia, thyroid dysfunction, and short stature, are associated with chromosome 22q11.2 microdeletion syndrome. This study was undertaken to examine the frequencies and clinical features of endocrine abnormalities in patients with 22q11.2 microdeletion syndrome. METHODS: We analyzed 61 patients with 22q11.2 microdeletion syndrome diagnosed based on the verification of microdeletion by fluorescent in situ hybridization (FISH) using a probe of the DiGeorge syndrome critical region (TUPLE1) at 22q11.2 and a control probe, ARSA at 22q13. Serum total calcium, phosphorus, and intact parathyroid hormone (PTH) levels were measured, thyroid function test was performed, and serum IGF-1 and IGFBP-3 levels were also estimated. Height and weight of patients were compared with individual chronological ages. RESULTS: Hypocalcemia was found in 20 patients (32.8%), and overt hypoparathyroidism in 8 (13.1%). Two patients (3.3%) showed autoimmune thyroid diseases, 1 each with Graves' disease and Hashimoto thyroiditis. Ten patients (16.4%) were below the third percentile in height, but the serum IGF-1 level was normal in 9 out of these 10 patients. CONCLUSION: Our findings show that patients with chromosome 22q11.2 microdeletion syndrome present with variable endocrine manifestations and variable clinical phenotypes. In addition to FISH analysis, careful endocrine evaluations are required in patients with this microdeletion syndrome, particularly for those with hypoparathyroidism or thyroid dysfunction.

Body Height↗