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PubMed · 619114

USP dissolution test II: Sigmoid dissolution profiles from directly compressed tablets.

J T Carstensen·J L Wright·K W Blessel·J Sheridan
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Abstract

The basic steps involved in the dissolution of a directly compressed tablet in a USP basket dissolution apparatus were examined via data generation. The proposed model explains why a dissolution curve can be sigmoid shaped and why the portion past the lag time has a log-linear undissolved mass versus time correlation.

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J T Carstensen, J L Wright, K W Blessel, J Sheridan. 1978. USP dissolution test II: Sigmoid dissolution profiles from directly compressed tablets.. https://doi.org/10.1002/jps.2600670113

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