PubMed · 590901
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W Meinhof. 1977-12-08. [Systemic mycoses. 8. Therapy].. https://pubmed.ncbi.nlm.nih.gov/590901/
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In a 40-year-old farmer's wife presenting with fatigue, shortness of breath on exertion and occasional extrasystoles a space-occupying lesion of the mediastinum leading to obstruction of venous return in the superior vena cava was found. Prior to intended surgery the patient suddenly died following cerebral haemorrhage. Actinomycosis of the mediastinum leading to almost complete stenosis of the superior vena cava was found at necropsy.
Recent reports suggest a relationship between intrauterine contraceptive device (IUD) use and colonization or infection of the genital tract with Actinomyces species. This prospective, case-controlled study was designed to determine the incidence of colonization or infection with Actinomyces in IUD users. None of 50 control patients and four of 50 study patients (8%) had Actinomyces identified. None of the patients with positive results had symptomatic pelvic infection. Cervical cytology was effective in detecting each of the four study patients with positive results. It appears that the presence of any type of IUD is a major predisposing factor to colonization with Actinomyces.