PubMed · 5884586
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H Sato, Y Otsuji. 1965. [Filariasis].. https://pubmed.ncbi.nlm.nih.gov/5884586/
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Although successful treatment of loiasis with diethylcarbamazine (DEC) has been reported, little is known about the long-term success rate of therapy or the predisposing factors for treatment failure. To address these questions, 32 patients were followed 2-15 years (median, 4.5) after DEC treatment; all had acquired infection while expatriate visitors to endemic areas of Africa. Using a strict definition of successful treatment, 12 (38%) appeared to be cured after one course of therapy and 5(16%) after two courses. Of the remaining 15 patients, 3 continued to be symptomatic despite more than four courses of treatment. Although 12 of the 17 patients who relapsed did so within 1 year of treatment, several had relatively long asymptomatic periods (2-8 years). There was no predictive difference in clinical or laboratory parameters (including eosinophilia and specific filarial serology) between patients requiring one or more courses of therapy.
In filariasis control in Indonesia, various regimes of DEC administration have been tried out with good results. However, the higher dosage regimes gave severe reactions. Since a trial with low dosage administration by community leaders gave very good results with minimal side effects, the execution of the control program was handed over to the Primary Health Care unit whose personnel trained community leaders to recognize the symptoms of the disease, distribute the drugs and treat side effects when they occurred. Communicable disease control through health care approach is now being promoted. The activities in the Integrated Services post are carried out by volunteers through village organizations supervised by the health care unit was established, using 1 cadre to look after the health of 10 households.
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