PubMed · 5830681
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C Valette. 1965-04-25. [Appendicular occlusion].. https://pubmed.ncbi.nlm.nih.gov/5830681/
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BACKGROUND: Appendicitis is an uncommon diagnosis in very young children. It is frequently complicated by delays in diagnosis, perforation, and lengthy hospital stays. OBJECTIVES: To review our recent experience with appendicitis among children younger than 3 years old, and to identify the independent predictors of a prolonged hospital stay. METHODS: A retrospective case series review was performed on all children under age 3 who had an appendectomy for appendicitis between January 1983 and February 1994. Multiple regression analysis was used to identify the independent predictors of a prolonged hospital stay. RESULTS: Sixty-three children were identified. Mean age was 2.2 years (range 11 to 35 months). The mean delay from onset of symptoms to presentation was 4.3 days. Fifty-seven percent were initially misdiagnosed. Diarrhea was reported in 33%. Perforation and/or gangrene were found in 84%. Perforation and/or gangrene at laparotomy and a history of diarrhea at presentation were independent predictors of a prolonged hospital stay. CONCLUSIONS: Appendicitis in children under 3 years old is characterized by delays in diagnosis and perforation. A history of diarrhea is an important factor that confuses the diagnosis, prolongs the observation period, and delays appropriate therapy.
In Hacettepe University Children's Hospital, between 1976 and 1993 two patients among 302 with Hirschsprung's disease were diagnosed with appendiceal perforation (AP) at initial admission. Both patients were less than 2 months of age. One of them was a boy with total colonic aganglionosis and the latter a girl with long-segment disease. In both cases the site of AP was the base, and periappendicitis without mucosal involvement was detected. The present cases and review of the literature suggest that longer aganglionic segment carries a higher risk of AP.
BACKGROUND: The influence of patient preference and treatment costs has not been considered in previous analyses of wound management decisions for contaminated right lower quadrant incisions. STUDY DESIGN: We performed a decision and cost-utility analysis, conducting a MEDLINE search of the postappendectomy wound infection literature to establish assumptions and assign baseline probability estimates. Institution-specific cost data were obtained, and utility assignments were made by the authors. Studies used to assign baseline probabilities fulfilled the following criteria: perforated appendix or gangrenous appendicitis, use of perioperative antibiotics active against aerobic and anaerobic bacteria, and data stratified by wound management, operative findings, and infection rate. RESULTS: We constructed a decision tree comparing three methods of wound management for contaminated right lower quadrant incisions: primary closure, delayed primary closure, and secondary closure. Utility (a quality of life measure) was assigned to ultimate health states to incorporate patient preference. We calculated the cost-utility for each method of wound management and found that primary closure was of optimum cost-utility compared with delayed primary closure and secondary closure. To gain one quality-adjusted life year treating a population of patients with contaminated incisions, primary closure saves $22,635 over delayed primary closure and another $22,340 over secondary closure. This decision, tested by two-way sensitivity analyses, was sensitive only to high primary closure infection rates. CONCLUSIONS: Challenging traditional surgical dogma, cost-utility analysis shows that primary closure is the favored method of management for contaminated right lower quadrant incisions. This analysis is specific to right lower quadrant incisions and the conclusion is valid for all estimated primary infection rates less than 0.27.