PubMed · 5553166
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H Klepzig. 1971-04-23. [Difference between alpha- and beta-acetyldigoxin].. https://pubmed.ncbi.nlm.nih.gov/5553166/
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The interior of cage-like molecules can be considered to provide a new phase of matter, in which it becomes possible to stabilize reactive intermediates and to observe new forms of stereoisomerism. Cage-like molecular complexes that self-assemble through weak intermolecular forces are dynamic species, encapsulating guest molecules reversibly. They can persist over timescales ranging from microseconds to hours, long enough for chemical processes to take place within them. Here we report the acceleration of a Diels-Alder reaction by encapsulation of the reactants in a self-assembling molecular capsule. Although product inhibition (lack of dissociation) prevents the system from showing true catalytic behaviour, there is clear evidence for a rate increase of over two orders of magnitude owing to the effective enhancement of concentration inside the capsule.
Adenine, thymine and cytosine PNA monomers have been prepared using 3-amino-1,2-propanediol as a starting material. The benzoyl group was used to protect the exocyclic amines of the heterocyclic bases of A and C PNA monomers and the backbone primary amine was protected with the monomethoxytrityl group. The thymine and cytosine PNA monomers were used in conjunction with standard DNA synthesis monomers to produce chimeric PNA DNA (PDC) oligomers. Ultraviolet melting studies confirmed that these oligomers form stable hybrids with complementary DNA strands and that mismatches in the DNA but more so in the PNA sections lead to duplex destabilisation.