Search PubMed⌕ Search
Home/Archive/PubMed

PubMed · 533441

[Toxic retinopathies].

J François
View original source ↗Export metadata ↓

Abstract

Among the drugs, which are topically administered, only epinephrine may produce retinal changes (macular oedema) in aphakic patients. Among the drugs, which are systemically administered, some immunodepressors, ethambutol, indomethacine, digitalis, but particularly chlorpromazine, thioridazine, quinine and chloroquine may produce toxic retinopathies. Concerning the intraocular metallic foreign bodies, siderosis is much more toxic for the retina than chalcosis.

Explore related subjects

ChloroquineCopperDigitalis GlycosidesEpinephrineEthambutolHumansImmunosuppressive AgentsIndomethacinLysergic Acid DiethylamideOphthalmic SolutionsPhenothiazinesQuinineRetinal DiseasesSiderosisEnglish AbstractJournal Article

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

J François. 1979. [Toxic retinopathies].. https://pubmed.ncbi.nlm.nih.gov/533441/

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed2006

Uncertainty evaluation in the chloroquine phosphate potentiometric titration: application of three different approaches.

A measurement result cannot be properly interpreted if not accompanied by its uncertainty. Several methods to estimate uncertainty have been developed. From those methods three in particular were chosen in this work to estimate the uncertainty of the Eu. Ph. chloroquine phosphate assay, a potentiometric titration commonly used in medicinal control laboratories. The famous error-budget approach (also called bottom-up or step-by-step) described by the ISO Guide to the expression of Uncertainty in Measurement (GUM) was the first method chosen. It is based on the combination of uncertainty contributions that have to be directly derived from the measurement process. The second method employed was the Analytical Method Committee top-down which estimates uncertainty through reproducibility obtained during inter-laboratory studies. Data for its application were collected in a proficiency testing study carried out by over 50 laboratories throughout Europe. The last method chosen was the one proposed by Barwick and Ellison. It uses a combination of precision, trueness and ruggedness data to estimate uncertainty. These data were collected from a validation process specifically designed for uncertainty estimation. All the three approaches presented a distinctive set of advantages and drawbacks in their implementation. An expanded uncertainty of about 1% was assessed for the assay investigated.

Chloroquine↗
PubMed2006

In vitro inhibition of human influenza A virus replication by chloroquine.

Chloroquine is a 9-aminoquinolone with well-known anti-malarial effects. It has biochemical properties that could be applied to inhibit viral replication. We report here that chloroquine is able to inhibit influenza A virus replication, in vitro, and the IC50s of chloroquine against influenza A viruses H1N1 and H3N2 are lower than the plasma concentrations reached during treatment of acute malaria. The potential of chloroquine to be added to the limited range of anti-influenza drugs should be explored further, particularly since antiviral drugs play a vital role in influenza pandemic preparedness.

Chloroquine↗