PubMed · 5328342
The source did not provide an abstract. Follow the original record for more information.
Explore connections, maps & timelines
K Yamaoka, M Yamaguchi, S Naito. 1966. [Haptoglobin].. https://pubmed.ncbi.nlm.nih.gov/5328342/
Cite the original work for its findings. Save a collection to share your selection of sources.
KEEP EXPLORING
Measurement of serum haptoglobin by immunoturbidimetry was markedly interfered with hemolysis because of haptoglobin-hemoglobin complex formation. Turbidity formed with haptoglobin and immunoglobulin complexes was gradually decreased by the addition of hemoglobin in the reaction mixture, and reached to a certain fixed levels when serum haptoglobin were saturated with hemoglobin. The turbidity derived from saturated haptoglobin and hemoglobin complex closely correlated with the haptoglobin level without hemoglobin. Thus, we could measure the corrected haptoglobin level in hemolytic specimen by the saturation of hemoglobin in reaction mixture.
Serum haptoglobin level and its phenotypes were studied in 208 normal people and 176 malignant lymphoma patients consisting of 112 Non-Hodgkin's Lymphoma (NHL) and 64 Hodgkin's Disease (HD) at Tata Memorial Hospital, Bombay and were correlated with the clinical stages of the lymphomas. Haptoglobin (Hp) levels were also estimated in the patients at different intervals during their chemotherapy. Hp level was found significantly increased to 147.83 +/- 8.67 in NHL and 173.57 +/- 13.31 in HD as compared to 67.46 +/- 2.53 in the controls. The phenotypic and gene frequencies in the lymphoma patients did not differ significantly from those of the controls. All the clinical stages, except stage I, of NHL and HD revealed significant rise in Hp level when compared with the controls. When different clinical stages of NHL and HD were compared separately, HD showed significant rise in HP level over the NHL only in Stage IV (p less than 0.05). Significant reduction in Hp level was observed when the disease regressed due to chemotherapy but it again increased with the relapse of the disease. Thus, the study of serum haptoglobin levels at intervals in lymphoma patients would help to understand the regression or relapse of the disease and also the prognosis.
It was found that patients with pulmonary tuberculosis recurrences revealed an imbalance between the elevated level of lipid peroxidation and possibilities of antioxidant protection. The proteinase inhibitor system balance was disturbed. The general level of haptoglobulin rises while the number of persons with homozygote of haptoglobulin 2:2 rose and the number of persons with the heterozygote phenotype 2:1 reduced. Normalization of the biochemical indices in patients with recurrences was delayed.