PubMed · 5224478
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T E Dunn. 1966. The simple bone cyst.. https://pubmed.ncbi.nlm.nih.gov/5224478/
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We report a case of a solitary bone cyst in the mandible of an elderly woman who presented with a bilateral radiolucent lesion that caused bony expansion, and which recurred 30 months after enucleation and bone grafting of the cavity.
In order to define the histogenesis of bone solitary cyst it was performed immunohistochemical study of surgical material obtained from 17 patients with the monoclonal antibodies against the following antigens: CD-31 (marker of endotheliocytes), IV type collagen (marker of blood vessel basal membrane), vimentin (marker of connective tissue) and Ki-67 (marker of mitotic cell). The results of the study showed, that solitary bone cyst shouldn't be attributed to the blood-vessel formations and because of its vimentin-positive peculiarity it has connective tissue genesis. At the same time bone cyst shouldn't be considered as tumoral process because it contains low quantity of mitotic cells' markers and the latter appears on the peripheral region of an active cyst, where the regeneration and intensive transformation of bone tissue take place. According to the above-mentioned the solitary cyst of bone should be considered as non-tumor connective-tissue pathology, histogenesis of which shouldn't be related to blood vessels.
Epiphyseal extension of benign pathology is regarded as an infrequent occurrence. This observation has been attributed to anatomical and biochemical phenomenon unique to physeal cartilage. We report a retrospective series of six patients over a period of 4 years, diagnosed with benign pathologies that showed crossing of an open physeal plate by the disease. Four of these cases were infections and two were benign tumors. The patients were aged between 5 and 11 years, all of them were treated at a tertiary referral centre and followed up for a minimum period of 6 months to evaluate the progress of disease. The findings are more than just a pathological curiosity as they alter the management and surgical procedure that needs to be performed for these conditions. The recognition of the fact that benign tumors may occasionally present with transphyseal spread will prevent unjustified radical procedures that are best reserved for aggressive malignant conditions.