PubMed · 5197616
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V Moia. 1969. [Pulmonary function tests].. https://pubmed.ncbi.nlm.nih.gov/5197616/
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An inexpensive system has been devised for the efficient transfer of Xe-127 gas from the manufacturer's ampule into individual dose vials for patient use. By displacing the gas with an aqueous solution, the initial transfer is made from an ampule of known activity into an evacuated serum vial of predetermined volume with transfer efficiency greater than 99%. A similar principle is used to transfer Xe-127 from the stock serum vial into individual dose vials, with total xenon recovery exceeding 98%. Ability to deliver the desired activity to each vial is within 90-110% of that predicted by calculation. Reproducibility in delivering a given activity was excellent, with all vials falling between 95 and 105% of the mean activity. Stability studies showed that 94% of the Xe-127 activity can be removed from the vials with only 6% absorbed in the rubber stopper after 5 wk of storage. The device costs less than $25.00 and can be constructed easily from common laboratory materials.
Xenon-127, which provides photon energies better suited to the Anger camera and reduces radiation dosage to the patient compared with Xe-133, has become commercially available from Brookhaven Laboratories. Its higher cost and longer shelf-life require improved handling and dispensing of shipment ampoules containing gas of high specific activity. The technique described permits individual doses to be prepared for gaseous administration, or dissolved in saline for i.v. injection.