PubMed · 5181745
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[Injections].. https://pubmed.ncbi.nlm.nih.gov/5181745/
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PURPOSE: To assess the accuracy and precision of methods in clinical use for intraocular drug injection. DESIGN: Experimental laboratory investigation. METHODS: A total of 800 injections were performed using 20 different 1-ml syringes at intended volumes of 0.10 ml and 0.05 ml. The volume of each injection was calculated from mass of water delivered onto an analytic balance. RESULTS: The mean measured volume delivered was less than the intended volume for every syringe (P <.001 for each syringe at each volume). A total of 7% and 22% of injections differed by 20% or more from the intended volumes of 0.10 ml and 0.05 ml, respectively. Overdelivery of volume was uncommon. CONCLUSION: Clinically relevant materials and methods used for intraocular injection of drugs systematically underdelivered the intended volume.
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