PubMed · 5170121
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M Suda. 1971. [Peptide hormones].. https://pubmed.ncbi.nlm.nih.gov/5170121/
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Antagonist activity can be measured either as the percentage reduction in the effect of an agonist or as a dose ratio. In this article, Dick Barlow explains how these are connected and how the relationship between the concentration of antagonist producing 50% inhibition (IC50) and the antagonist equilibrium constant (Ki) involves the degree of agonist stimulation ([A]/[A50]), which is the concentration of agonist expressed as a multiple of the concentration producing a half-maximal response. If Ki is known it is possible to use the IC50 value of the antagonist to estimate the degree of agonist stimulation in physiological experiments where there is neuronal or hormonal release of the agonist.
In a brief review of advances made in endocrinology during the past two years, focused on steroid hormones, the author discusses findings on mineral corticoid and glucocorticoid receptors and their interaction with hormone responsive elements in nuclei of target cells. The antimicrobial action of some steroid hormones and general characteristics of the cell reaction to stress (proteins of heat shock) are also new findings. In the region of peptide hormones the author mentions findings pertaining to the mechanisms of development of adenohypophyseal adenomas, probably by the action of GHRH. It is assumed that some derivatives of prostaglandins will have an antiviral and anti-tumorous effect. An endogenous ligand for tetra-hydro-cannabinol receptors was isolated. Preventive administration of insulin protects relatives of patients with diabetes mellitus type I from the development of the disease.