PubMed · 4936315
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V Harkóv. 1971-06-13. [Henry E. Sigerist].. https://pubmed.ncbi.nlm.nih.gov/4936315/
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The Mediterranean population of tomato leaf curl New Delhi virus (ToLCNDV-ES) is characterized by a high genetic uniformity, distinguishing it from its Asian counterparts. ToLCNDV-ES is thought to have a monophyletic origin, likely resulting from a single recombination event, prior to its spread throughout the Mediterranean region. Following its first detection in southeastern France in 2020, ToLCNDV-ES re-emerged in France in 2022. Our analysis based on advanced long-read sequencing, circular DNA profiling, and phylogeny indicates both local persistence of French ToLCNDV-ES and multiple independent introduction events. Signatures of positive selection were identified in French ToLCNDV-ES populations, whereas no clear evidence of recombination was found. Bayesian time-structured phylogenetic analyses suggest that introductions in France occurred between 2018 and 2021 from the major ToLCNDV-ES clade, while several Italian ToLCNDV-ES isolates diverged prior to the virus introduction in the Mediterranean basin. Overall, this study demonstrates the value of an optimized long-read sequencing approach for resolving circular DNA virus diversity, and sheds light on the complex evolutionary history of ToLCNDV-ES in the Mediterranean Basin, particularly in southeastern France.
Almost 40 years of lucky existence is enough time for questioning and/or updating the Stoppa method for hernia repair. In this paper, the author reports the circumstances of the birth of this method more than 30 years ago, recalls its innovative principles, describes its technical aspects, and exposes its good results. Not simply approving old concepts, the author concludes with critical remarks with regard to a so-called political correctness of today's groin hernia repair, which gives great importance to reducing patient trauma arising from surgery. For belief without doubt can be wrong belief!