PubMed · 4890321
The source did not provide an abstract. Follow the original record for more information.
Explore connections, maps & timelines
T Komai. Pavlov and genetics.. https://doi.org/10.1093/oxfordjournals.jhered.a107728
Cite the original work for its findings. Save a collection to share your selection of sources.
KEEP EXPLORING
Explore the source record for details and available documents.
Magnetoencephalography (MEG) was recorded during aversive classical conditioning in an attempt to elucidate the temporal coding of primary somatosensory cortex (SI) activation previously found with positron emission tomography. Four healthy volunteers participated in the experiment. The reinforced conditioned stimulus was displayed on a screen for 2 s, and as it disappeared an unconditioned electric shock to the right middle finger followed. A control stimulus, not paired with a shock was also presented. With MEG, we observed a conditioned magnetic response located in the SI. The conditioned response predated the shock presentation and is interpreted as evidence for functional control of nociception mediated by corticothalamic projections.
Two methods are presented for the data analysis of signals derived by subtracting conditioned from control reflex data in full-wave rectified and averaged electromyographic (EMG) signals. The first method uses the ratios of the mean amplitudes and standard errors of the mean (S.E.M.s) (i.e. Student's t values) of a series of data points in such a difference signal, and deals with the detection of latencies of reflex components which are susceptible to a conditioning stimulus or experimental situation. The second method applies a modified cumulative sum (CUSUM) technique to full-wave rectified difference signals. This modified CUSUM technique determines the magnitude of the effects of the conditioning situation above that expected due to chance fluctuations, taking into account the effect of reflex modulations on such chance fluctuations in a post-stimulus period. The modified CUSUM technique proved particularly useful when various subtle but consistent, opposing changes occurred sequentially in the conditioned series thus yielding a complicated pattern of effects in a difference signal, with a low signal-to-noise ratio.