PubMed · 4874852
The source did not provide an abstract. Follow the original record for more information.
Explore connections, maps & timelines
L Polak. 1967-11-01. [Calcitonin].. https://pubmed.ncbi.nlm.nih.gov/4874852/
Cite the original work for its findings. Save a collection to share your selection of sources.
KEEP EXPLORING
BACKGROUND: Metastatic tumors to the oral cavity are rare, representing about 1% of oral tumors, and they affect jaws more often than the oral soft tissues. METHODS: Fifteen cases of metastases to the jaw bones from thyroid carcinoma were found in a recent review, with no cases located in the oral mucosa. RESULTS: The authors describe the first cases of gingival metastasis from a thyroid medullary carcinoma. CONCLUSIONS: Periodontists must recognize oral soft tissue metastases because they can be the first sign of an undiscovered malignancy, and they can be easily mistaken with several different benign lesions.
The influence of beta-cyclodextrin (betaCD), and various betaCD derivatives, on both the chemical and the physical stability of the polypeptide hormone salmon calcitonin (sCT) in aqueous solutions was investigated at elevated temperature (55 degrees C). Also, the influence of various betaCD derivatives on the enzymatic degradaton of sCT was evaluated. At pH 6, the effect of CDs on the chemical stability of sCT was negligible at CD concentrations below 5% (w/v). The only exception was the negatively charged carboxymethyl-betaCD (CMbetaCD), which increased sCT stability. The charged CDs, i.e. 2-hydroxytrimethylammonio-propyl-betaCD (TMAbetaCD) and CMbetaCD, promoted degradation in concentrated solutions of sCT at pH 6. 2-Hydroxypropyl-betaCD (HPbetaCD) and randomly methylated betaCD (RMbetaCD) not only inhibited aggregation, they also solubilised dimers formed in the test solutions, thereby increasing the physical stability. All the CDs tested accelerated the alpha-chymotryptic degradation of sCT. Maltosyl-betaCD (G(2)betaCD), HPbetaCD and RMbetaCD showed an inhibition of leucine aminopeptidic and tryptic degradation.
Explore the source record for details and available documents.