Search PubMedSearch

PubMed · 48731

Sunlight and hypercalciuria.

Abstract

Urinary calcium and magnesium excretion was measured in two groups of soldiers leaving the temperate climate of the united Kingdom for service in the Persian Gulf. In one group urinary calcium levels and magnesium/calcium ratios were similar, ten days after arrival in the Gulf during the "cold season", to those found in the U.K. The other group went to the Gulf in the "hot season", and calcium excretion rose immediately to levels comparable with those found in the first group after eight months. Mg/Ca ratios fell to levels seen in stonformers, and 2 of 91 soldiers followed up for three years have had urinary calculi. Increased exposure to sunlight seems to be the most likely cause of the hypercalciuria.

Explore related subjects

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

E S Parry, I S Lister. 1975-05-10. Sunlight and hypercalciuria.. https://doi.org/10.1016/s0140-6736(75)91830-9

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

Adaptation to climate across the Arabidopsis thaliana genome.

Understanding the genetic bases and modes of adaptation to current climatic conditions is essential to accurately predict responses to future environmental change. We conducted a genome-wide scan to identify climate-adaptive genetic loci and pathways in the plant Arabidopsis thaliana. Amino acid-changing variants were significantly enriched among the loci strongly correlated with climate, suggesting that our scan effectively detects adaptive alleles. Moreover, from our results, we successfully predicted relative fitness among a set of geographically diverse A. thaliana accessions when grown together in a common environment. Our results provide a set of candidates for dissecting the molecular bases of climate adaptations, as well as insights about the prevalence of selective sweeps, which has implications for predicting the rate of adaptation.

Acclimatization

The effects of exercise and diet manipulation on the capacity to perform prolonged exercise in the heat and in the cold in trained humans.

1. This study examined the effects of exercise and diet manipulation intended to alter initial muscle glycogen levels on the capacity to perform prolonged exercise at two ambient temperatures. 2. Six well-trained cyclists participated in randomized order in two diet and exercise regimens each lasting 8 days and comprising four cycle tests to exhaustion at 70 % of maximum oxygen uptake. On days 1 and 5, subjects exercised to exhaustion to deplete muscle glycogen. Three days after each depletion trial a diet providing 10 % (low carbohydrate (CHO)) or 80 % (high CHO) of energy as CHO was consumed, and each diet was followed by a performance trial at the same ambient temperature, either 10 or 30 C (days 4 and 8). This schedule was repeated after a week, but performance trials were carried out at the other ambient temperature. 3. In the cold, cycling time increased (median (range)) from 89.2 min (78.0-129.5 min) on the low CHO trial to 158.2 min (116.9-165.6 min) on the high CHO trial (P < 0.01). In the heat, cycling time increased from 44.0 min (31.8-51.4 min) on the low CHO trial to 53.2 min (50.2-82.2 min) on the high CHO trial (P = 0.02). Total CHO oxidized during exercise in the cold after the low CHO diet was higher than in the heat after either diet suggesting that exercise in the heat was terminated before all available CHO stores had been emptied.

Acclimatization

Adaptive hypoxic tolerance in the subterranean mole rat Spalax ehrenbergi: the role of vascular endothelial growth factor.

Spalax ehrenbergi has evolved adaptations that allow it to survive and carry out normal activities in a highly hypoxic environment. A key component of this adaptation is a higher capillary density in some Spalax tissues resulting in a shorter diffusion distance for oxygen. Vascular endothelial growth factor (VEGF) is an angiogenic factor that is critical for angiogenesis during development and in response to tissue ischemia. We demonstrate here that VEGF expression is markedly increased in those Spalax tissues with a higher capillary density relative to the normal laboratory rat Rattus norvegicus. Upregulation of VEGF thus appears to be an additional mechanism by which Spalax has adapted to its hypoxic environment.

Acclimatization