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PubMed · 4843792

Amino acid difference formula to help explain protein evolution.

R Grantham
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Abstract

A formula for diference between amino acids combines properties that correlate best with protein residue substitution frequencies: composition, polarity, and molecular volume. Substitution frequencies agree much better with overall chemical difference between exchanging residues than with minimum base changes between their codons. Correlation coefficients show that fixation of mutations between dissimilar amino acids is generally rare.

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Amino AcidsBiological EvolutionGenetic CodeMathematicsModels, BiologicalMutationProtein BiosynthesisProtein ConformationRNA, MessengerJournal Article

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R Grantham. 1974-09-06. Amino acid difference formula to help explain protein evolution.. https://doi.org/10.1126/science.185.4154.862

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