PubMed · 4715064
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D Morley. 1973. Measles prophylaxis.. https://doi.org/10.1177/004947557300300314
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Numerous biological factors can modify an individual's degree of immune response to vaccine. Such factors may complicate an immunogenicity trial by acting as counfounding variables; alternatively, their relationship to the measured antibody response may be the primary focus of an investigation. Standard regression analyses can adjust for many variables simultaneously and assess their relative importance, but require several conditions or assumptions. To reduce these requirements, we present a flexible regression model that allows for: (1) a broad class of shapes for the response distribution; (2) censoring of observations due to detection limits; and (3) the existence of a separate distribution of low-responders. We illustrate this modeling approach with neutralizing antibody data from a factorial study of measles vaccine. The effects of vaccine dose and strain, obscured by standard analyses, are elucidated by the new model.
Temperature-dependent growth restriction was studied with the measles vaccine strains licensed in Japan in comparison with their parental wild strains. Plaquing efficiency was compared at various temperatures from 35 to 40 C. AIK-C strain derived from Edmonston wild strain was temperature-sensitive with the 39 C shutoff temperature. No significant restriction of growth was found for other vaccine strains, i.e., Schwarz, FF-8, and CAM-70, and for their parental wild strains, i.e., Edmonston and Tanabe . A paradoxical feature was found for FF-8 strain; in spite of undiminished plaquing efficiency at 40 C, the growth in the fluid medium was markedly depressed at 39 C or above.
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