PubMed · 4705895
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T Nasemann. 1973-04-20. [Psoriasis].. https://pubmed.ncbi.nlm.nih.gov/4705895/
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Bacteria with the ability to use 5-chloro-2-hydroxynicotinic acid as sole source of carbon and energy have been isolated from enrichment cultures with 2-hydroxynicotinic acid and 5-chloro-2-hydroxynicotinic acid. According to their morphological and physiological properties, these bacteria have been classified as Mycobacterium sp. The first metabolite in the degradation pathway is 5-chloro-2,6-dihydroxynicotinic acid. 2-Hydroxynicotinic acid had an inductive effect on the degrading enzymes. Chloride was released from 5-chloro-2-hydroxynicotinic acid, chloromaleic acid and chlorofumaric acid. A degradation pathway is proposed.
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Rhizobium sp. strain ORS571 conducts synergistic, free-living N2 fixation and nicotinate oxidation. Explicitly, ORS571 is able to fix N2 aerobically because 6-OH-nicotinate acts as an intracellular O2 sink. Because 6-OH-nicotinate oxidation is mandatory for aerobic, free-living N2 fixation and because the synergistic processes yield ammonium from substrates (as the nitrogen source for growth), ORS571 is not a diazotroph.