PubMed · 457302
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K S Chugh, V Sakhuja. 1979. Acute copper intoxication.. https://pubmed.ncbi.nlm.nih.gov/457302/
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The diversity and predominance of nematode genera in goats of resource-poor farmers at Rust de Winter, Gauteng Province, Impendle, KwaZulu-Natal Province, and Kraaipan, North-West Province, South Africa, was determined by means of a longitudinal study of the nematode faecal egg counts (FECs) and differential third-stage nematode larvae. The animals were bled for haematocrit determination and scored for pallor of ocular mucous membranes using the FAMACHA( Copyright) method, an assay for clinical evaluation of anaemia caused by Haemonchus spp. Animals considered to be in danger of dying from anaemia caused by haemonchosis were selectively treated with an anthelmintic. Lower haematocrit values were registered during periods of heavier Haemonchus infection, which occurred from December/January to March for Rust de Winter; from December to March/April for Impendle; and from November/December to February or April for Kraaipan. There was agreement too between the lower haematocrits and paler mucous membranes scored according to the FAMACHA( Copyright) method. The use of this system may be recommended as part of an integrated approach to worm control in goats kept in the resource-poor areas studied.
BACKGROUND: Seven computer-based Nutrition in Medicine interactive modules for teaching nutrition are available for instruction in medical schools. OBJECTIVE: The goal of this study was to evaluate the instructional efficacy of the Nutritional Anemias and the Diabetes and Weight Management: Aberrations in Glucose Metabolism modules when used by first-year medical students. DESIGN: The modules were introduced at Meharry Medical College to enhance its nutrition course for first-year medical students. Eighty medical students used the Anemias and Diabetes modules as an obligatory component of the course. Students were divided into 20 study groups of 4 and were required to answer multiple-choice questions to test their nutrition knowledge before and after use of the module. RESULTS: On average, students spent 1.89 +/- 0.99 h studying each module, and most students (70%) reported viewing modules in more than one session. The percentage of correct responses to 12 knowledge questions from each module increased from 25% before use of the module to 74% immediately after its use and remained high (59%) 8 mo later. The pattern of knowledge retention, however, had some unpredictability. On the midterm examination, 72% of the students correctly answered questions related to nutritional anemias and nutrition aspects of diabetes. This was a 15% increase in knowledge of these 2 areas when compared with results obtained from first-year medical students 1 y earlier who had not used the modules. CONCLUSIONS: The modules tested are effective tools for teaching nutritional and health issues of anemias and diabetes to first-year medical students.
Methylene blue trihydrate is used widely as a dye and therapeutic agent. Methylene blue was administered by gavage to 30 animals/sex/dose group in a 0.5% aqueous methylcellulose suspension at doses of 0, 25, 50, 100, and 200 mg/kg. Blood samples from 10 animals/sex/dose group were collected at the end of study weeks 1, 6, and 13. Methylene blue treatment resulted in methemoglobin formation and oxidative damage to red blood cells, leading to a regenerative anemia and a variety of tissue and biochemical changes secondary to erythrocyte injury. An early change was a dose-related increase in methemoglobin, where the response of rats and mice was similar in magnitude. Mice appeared to be more sensitive than rats to the formation of Heinz bodies and the development of anemia that was characterized by a decrease in hemoglobin, hematocrit, and erythrocyte count. Splenomegaly was apparent in all treated mice and in the 100 mg/kg (males only) and 200 mg/kg rats at necropsy. There was a dose-related increase in absolute and relative spleen weight for both species. Microscopic examination revealed increased splenic hematopoiesis in all mice treatment groups and in rats at the 50 mg/kg dose level and above. Splenic congestion and bone marrow hyperplasia were also observed in these rat-dose groups. Mice at the higher doses showed hematopoiesis in the liver and accumulation of hemosiderin in Kupffer cells. These gross and microscopic findings are consistent with the development of hemolytic anemia. A dose-related increase in the reticulocyte count during study weeks 6 and 13 suggested a compensatory response to anemia.