PubMed · 4479000
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K Wójcicki, C Sniezyński. 1974-08-16. [Cecal lymphosarcoma].. https://pubmed.ncbi.nlm.nih.gov/4479000/
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In two patients examination of the small intestine by enteroclysis was indicated on account of haemorrhage into the digestive tract and severe anaemia and in one patient the ultrasonographic picture arousing suspicion of Crohn's disease of the terminal ileum. Although in all instances previously colonoscopy was made, considered complete, in one instance also irrigoscopy, with a negative result, enteroclysis revealed and surgery confirmed extensive carcinomas of the caecum and colon ascendens. The authors discuss the value and problems of the applied diagnostic method.
The prognosis of colorectal cancer has not significantly changed during the last 30 years. While evaluation of tumour cell proliferation may provide prognostic information, results obtained so far have been contradictory Heterogeneity in tumour cell proliferation may explain these contradictions. With in vivo injection of iododeoxyuridine (IdUrd), estimation of labelling index (LI), S-phase transit time (Ts) and potential doubling time (Tpot) may be performed from a single sample. A total of 109 colorectal cancers were studied after in vivo injection of IdUrd before surgical removal. From each cancer, four to eight samples were processed for both flow cytometrical (FCM) and immunohistochemical (IHC) visualization of IdUrd incorporation. LI/IHC was morphometrically quantified at both the luminal border and the invasive margin of these tumours. LI was significantly higher at the luminal border compared with the invasive margin, although they were correlated with each other. Using combined IHC and FCM methods, rapidly growing colorectal cancers (high LI and/or low Tpot) showed an increased survival (significant for LI at the invasive margin and for Tpot at both the invasive margin and the luminal border) in the entire unselected material and for radically removed Dukes' B tumours. FCM data alone did not discriminate for survival, with the exception of Ts in diploid and radically removed Dukes' B tumours.