PubMed · 4454679
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B Truniger. 1974. [Water intoxication].. https://pubmed.ncbi.nlm.nih.gov/4454679/
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Our dialysis unit observed fluid noncompliance over a wide variety of patients. The consequences of fluid abuse that can include systemic and cardiovascular overload are a frequent clinic complication of hemodialysis patients. In spite of all our attempts, our dialysis unit continued to have a substantial group of patients who could not adhere to their fluid restriction. Our dialysis unit needed a novel program to help motivate patients to comply with diet/medication fluid regimens. A method that seems to work well in our dialysis unit is playing unit-wide games. We developed "The Fluid Game," an original patient education idea, for providing renal patients with a fun incentive to keep their interdialytic weight gains within acceptable limits.
BACKGROUND: The conventional method of measuring total body water by the deuterium isotope dilution method uses gas isotope ratio mass spectrometry (IRMS), which is both expensive and time-consuming. We investigated an alternative method, using Fourier transform infrared spectrophotometry (FTIR), which uses less expensive instrumentation and requires little sample preparation. METHOD: Total body water measurements in human subjects were made by obtaining plasma, saliva, and urine samples before and after oral dosing with 1.5 mol of deuterium oxide. The enrichments of the body fluids were determined from the FTIR spectra in the range 1800-2800 cm-1, using a novel algorithm for estimation of instrumental response, and by IRMS for comparison. RESULTS: The CV (n = 5) for repeat determinations of deuterium oxide in biological fluids and calibrator solutions (400-1000 micromol/mol) was found to be in the range 0.1-0.9%. The use of the novel algorithm instead of the integration routines supplied with the instrument gave at least a threefold increase in precision, and there was no significant difference between the results obtained with FTIR and those obtained with IRMS. CONCLUSION: This improved infrared method for measuring deuterium enrichment in plasma and saliva requires no sample preparation, is rapid, and has potential value to the clinician.
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