PubMed · 443521
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I F Russell. 1979. Auditory perception under anaesthesia.. https://doi.org/10.1111/j.1365-2044.1979.tb06282.x
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The induction characteristics of minaxolone, a water-soluble steroid anaesthetic, were studied in fit patients undergoing minor urological or gynaecological operations. Minaxolone acted as rapidly as thiopentone. A dose of 0.25 mg kg-1 did not always produce anaesthesia in patients who had not received premedication but 0.5 mg kg-1 was an adequate dose. Excitatory effects were less common with the higher doses of anaesthetic. These effects were usually slight and rarely interfered with the course of anaesthesia. Unlike propanidid, minaxolone did not prolong the duration of action of suxamethonium. Minaxolone is easy to administer and causes little venous damage.
Intravenous injection of barbiturates is followed by a depression of the respiratory centre depending on the dose. Blood carbon dioxide increases. This can be measured continuously in the expired air. In the same time blood oxygen modifies. The hypoxia produced by this depressant action was determined by a non-invasive transcutaneous blood gas measurement technique during the induction of anesthesia.