PubMed · 4404644
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1972-12-25. Vascular surgery.. https://pubmed.ncbi.nlm.nih.gov/4404644/
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Variations of abdominal vessels are common and there are many reports about this subject. We report numerous variations of the superior part of the abdominal aorta and renal vessels which were determined in a single cadaver.
BACKGROUND: Atherosclerosis is a systemic disease that underlies clinical cardiovascular disease. The radiographic finding of abdominal aortic calcific deposits is an indicator of the presence of aortic atherosclerosis and an independent predictor of cardiovascular disease events. Little is known about the heritability of aortic calcification. METHODS AND RESULTS: Original Framingham Heart Study cohort participants (2151) in 1109 extended pedigrees had a lateral lumbar radiograph. The presence and severity of abdominal aortic calcific (AAC) deposits at the levels of the first through fourth lumbar vertebrae was graded by a previously validated rating scale. Correlation coefficients were calculated in pairs of siblings, parent-offspring, and spouses. Age-, sex-, and multivariable-adjusted correlation coefficients for AAC were 0.52 for parent-offspring pairs and 0.20 for sibling pairs. In contrast, the multivariable-adjusted correlation for AAC in spouse pairs was -0.02. Using variance component methods implemented in SOLAR, the estimated heritability for age-, sex-, and multivariable-adjusted AAC was 0.49 (P<0.001). Thirty-one percent of the overall variance in AAC deposits was due to measured covariates, and 49% to heritable factors. CONCLUSIONS: In our large, population-based sample, heritable factors play a role in the presence and extent of abdominal aortic calcification. Thus, a substantial proportion of the variation in AAC is due to additive effects of genes, which have yet to be characterized. Measures of aortic atherosclerosis may provide heritable quantitative phenotypes for the genetic dissection of the complex condition of atherosclerosis in human populations.
STUDY DESIGN: An anatomic classification system was devised on the basis of operative reports and preoperative magnetic resonance imaging or computerized tomography from 139 patients who underwent laparoscopic anterior lumbar interbody fusion involving L4-L5. OBJECTIVE: To devise a classification system for laparoscopic exposure of the L4-L5 disc space that would allow prediction of the safest approach for any given vascular configuration. SUMMARY OF BACKGROUND DATA: The laparoscopic technique has gained acceptance at L5-S1 but has been less successful at L4-L5. The vascular bifurcation and the variability of the anatomy have led to difficulties with exposure. METHODS: Data were collected on 139 patients undergoing laparoscopic anterior lumbar interbody fusion involving the L4-L5 disc space. Operative notes and preoperative magnetic resonance imaging and computed tomography scans were reviewed, and a classification system was devised based on the aortic bifurcation and confluence of the left iliac vein with the vena cava. Three variations were identified. Complications, particularly ejaculatory dysfunction, were described. RESULTS: Three classification categories were described. Twenty-five patients (18%) were classified as category A (above the bifurcation of both vessels), 52 patients (37%) were classified as category B (below the bifurcation of both vessels), and 51 patients (37%) were classified as category C (between the left iliac artery and vein). There were 8 (5.8%) intraoperative and 17 (12.2%) postoperative complications. Ejaculatory dysfunction constituted the majority of the postoperative complications, representing 16% of the male population. The incidence of ejaculatory dysfunction correlated with exposure from the left side of the aorta or the left iliac artery. For two-level fusions from L4 to S1, the incidence of ejaculatory dysfunction was 63% for category A but 0% for categories B and C. An alternative approach was suggested for category A: exposing the disc space between the aorta and vena cava. CONCLUSION: The laparoscopic approach to L4-L5 is complicated by the variability of the vascular anatomy encountered during the exposure. Routine magnetic resonance imaging or computed tomography can be used to classify the vascular anatomy and plan the optimal approach. Avoiding the left side of the aorta or the left iliac artery may minimize the risk of ejaculatory dysfunction.